In colorectal cancer, upregulated SPP1 is associated with poor survival outcomes (64); miR-340 can inhabit the phosphatidylinositol 3-kinase/protein kinase B pathway, and miR-340 also contribute to the suppression of proliferation, migration, and invasion of gastric cancer via reducing the expression of SPP1 (65). This evidence concerns the gene SPP1 and colorectal cancer.