Cholecystokinin type A receptor (CCKAR) promoter has relatively high activity in pancreatic cancer cells when compared with normal cells, this tumor-specific promoter was modified for enhancing its activity to be used within pancreas cancer cells for directing BikDD expression, a powerful pro-apoptotic gene, demonstrating its effective and specific anticancer effect (154). The gene discussed is CCKAR; the disease is pancreatic neoplasm.