The specific tumor union of activator protein (AP-1) to uPAR promoter has been found in approximately 40% of CRC patients and 38.9% of them showed this specific tumor union in resected tumors in contrast to low or absent attachment in the corresponding normal mucosa, demonstrating the specific tumor activity of uPAR in CRC and not in normal tissues (149). This evidence concerns the gene PLAUR and colorectal carcinoma.