Currently, significant poor prognosticator in patients with penile cancer include lymph node positivity (27), metastatic nodes≥ 4 (28), AJCC stage ≥ III disease (26), pathologic stage of the primary tumor (29), histologic grade<G1 (30, 31), a tumor thickness≥ 5 mm (32), vertical growth pattern (33), age<53, Lactate Dehydrogenase (LDH)<188.5 U/L and Platelet-lymphocyte Ratio (PLR)<133.5 (34), p53 positivity (31), Human papillomavirus infection (35). This evidence concerns the gene TP53 and human papilloma virus infection.