As stated earlier, experimentally induced colon carcinogenesis in a rat and CRC cells showed interplay of the PO with miR-126/VAM-1 and miR-12/PI3K/AKT/mTOR, this is identified as a mechanism which in part mediate anti-proliferative and anti-inflammatory activity of PO polyphenols (134). This evidence concerns the gene PALS2 and colorectal carcinoma.