GSTP1 and malignant colon neoplasm: The in-vivo mouse model study on the relationship between APC gene and glutathione conjugating enzyme variant such as GSTP1, showed a six-fold increase in incidence of colon adenoma in ApcMin/+Gstp1/p2−−/−− (Gstp-null ApcMin) than in ApcMin/+ Gstp1/p2+/+ (Gstp-wt ApcMin)-the wild counterpart that rarely develops colon cancer (145).