GCLC and malignant colon neoplasm: Kim & colleagues reported that the levels of GSH and GSH synthetic enzymes in human colorectal cancer have shown that mRNA and protein expression of GSH, the catalytic subunit of GCL (GCLC), and GSS were significantly upregulated in five colon cancer cell lines: SNU-407, Caco-2, SNU-1033, HCT-116, and HT-29, when compared to the normal colon cell line, FHC (125).