For example, lncRNA cancer susceptibility 9 (CASC9) knockdown suppressed hepatocellular carcinoma (HCC) cell proliferation and induced cell apoptosis in vitro and hampered HCC xenograft tumor growth in vivo by binding with RBP heterogeneous nuclear ribonucleoprotein L (HNRNPL), where the CASC9-HNRNPL complex could co-regulate the expression of genes associated with AKT signaling pathway (20). This evidence concerns the gene HNRNPL and hepatocellular carcinoma.