Zoledronic acid is a nitrogen-containing bisphosphate with anti-tumor activity including decreased tumor volume and bone growth in primary EWS tumors, decreased recruitment of TAMs into the tumor stroma in murine sarcoma and carcinoma models (170–172), and reduction in bone metastases EWS after administration of ZA in murine in vivo models (171). The gene discussed is EWSR1; the disease is neoplasm.