TAMs are one of at least four myeloid subpopulations derived from tumor-associated myeloid cells (TAMCs) that also include myeloid-derived suppressor cells (MDSCs), tumor-associated neutrophils (TANs), and angiogenic monocytes expressing angiopoietin-2 (TIE-2) (29–31). This evidence concerns the gene ANGPT2 and neoplasm.