Although blockade of this ligand/receptor binding is typically studied for its effects on T cell function, preclinical models of PD-L1/PD-1 blockade using BALB/c Rag2−/−γc−/− mice (which do not have functional T cells) showed TAM-mediated efferocytosis and clearance of tumor cells (185). The gene discussed is CD274; the disease is neoplasm.