IRF3 and neoplasm: Figure 5A shows the enrollment of the upregulated transcription factor named interferon regulatory factor 3 (IRF3) in triggering the TLR-inflammatory cascade. In 5B, thrombin downregulation and its putative role in cell migration and tumor progression pathways. Figure 5C demonstrates the upregulated protein transthyretin and its participation in the stem cell differentiation process.