The expression of FGFBP1 with ESCC cases of tumor differentiation (p = 0.012), age (p = 0.045), and lymph node metastasis (p = 0.032) has more obvious relationship, rather than gender, tumor size, tumor location, pathological stage, and vascular invasion of clinical pathology features. Here, FGFBP1 is linked to esophageal squamous cell carcinoma.