The high expression of FGF2 was related to the tumor size (p = 0.026), gender (p = 0.047), and lymph metastasis (p = 0.007), while the expression of FGF2 was not correlated with the race, age, tumor site, and pathological stage of ESCC cases and so on (p > 0.05). Here, FGF2 is linked to esophageal squamous cell carcinoma.