Our previous study has identified that the p38/JNK pathway was activated in L3MBTL4 TGs [10], but it still remained unclear whether the p38/JNK pathway contributed directly to L3MBTL4-induced vascular remodeling and whether inhibition of the p38/JNK pathway could abolish the role of L3MBTL4. Therefore, we applied p38 specific inhibitor, SB203580 [21], and JNK specific inhibitor, SP600125 [22], in the current study to explore the role of p38/JNK during the process of L3MBTL4-induced elevated blood pressure, left ventricular (LV) hypertrophy, and vascular remodeling in hypertension. This evidence concerns the gene MAPK8 and hypertensive disorder.