NEFL and Alzheimer disease: Very recently it has been shown that BF-LPS is abundant in AD brain neocortex, and in later stages of the disease can encapsulate neuronal nuclei of the neocortical hexalayer into ‘LPS cage’ structures and in doing so impair the exit of neuron-specific messenger RNA (mRNA) transcripts such as synapsin (SYN) and the neurofilament light (NF-L) chain protein [44–46].