Considering the importance of pulmonary diseases in coronaviruses, the immunomodulatory effects highlighted are decreased production of prostaglandin E2 (PGE2), cyclooxygenase 2 COX2, and nitric oxide (NO) by macrophages; increased T cell proliferation and natural killer cell (NK) activity; and the intensification of the antibody response by B cells [130]. The gene discussed is PTGS2; the disease is lung disorder.