Since the current clinical treatments (e.g., intravenous administration of tissue-type plasminogen activator, early motor training, and physical therapy) could not result in complete functional recovery in ischemic stroke patients [54], construction of a multicellular EC-NPSC-based 3D neurovascular unit model might be an alternative tissue engineering approach for regeneration of stroke-affected neuronal tissue. The gene discussed is PLAT; the disease is stroke disorder.