A previous study identified GRP78 protein from gastric cancer cell lines MkN-1, MkN-45, and KATOIII in Japanese patients with GC by SERPA, while it lacked the validation in a large population and reported the presence of anti-GRP78 antibody in sera from 17/60 (28.3%) patients with gastric cancer and 0/20 (0.0%) of healthy individuals on western blot analysis [15]. The gene discussed is HSPA5; the disease is gastric cancer.