We then collected 14 genes encoding chemokines including CCR7, CCL3, CCL4, CCL19, CCL21, CXCL10, CXCL11, CCL7, CXCL1, CXCR4, CCL1, CCL17, CCR4, and CCL28, which were also transcriptionally regulated by the transcription factors involved in cell cycle such as TP53 and MAX, and found that these genes were highly enriched in the downregulated genes in HCC with TP53/MAX deletions (Figures 4A,B; false discovery rate (FDR) < 0.05), indicating that the CNV loss in TP53/MAX might downregulate their target genes, thereby weakening the immune-cell recruitment. The gene discussed is CXCR4; the disease is hepatocellular carcinoma.