TSC1 and cancer: In the present study, we identified a series of cancer driver genes triggered by CNAs such as CDKN2B, MYC, TSC1, TP53, and GSK3B, which were enriched in the frequently amplified and deleted regions, respectively, and well-characterized in several cancers (Zack et al., 2013; Tokheim et al., 2016; Bailey et al., 2018).