As chemokines secreted by the tumor cells played vital roles in immune-cell recruitment in TME (Chow and Luster, 2014) and were transcriptionally regulated by transcription factors such as TP53 (Blagih et al., 2020), consistently, we found that these genes were highly enriched in the downregulated genes in HCC with TP53/MAX deletions, which gave us a hint that the CNV loss in TP53/MAX might downregulate their chemokine-relayed target genes, thereby weakening the immune-cell recruitment. Here, TP53 is linked to hepatocellular carcinoma.