Loss of p53 function has been confirmed to decrease T-cell infiltration in breast cancer (Pinato et al., 2020), Accordingly, the downstream oncogenic pathway, cell cycle, was significantly activated in the low T-cell infiltration HCC, suggesting that the deletions in MAX or TP53 regulated T-cell infiltration by enhancing uncontrolled cell cycle. This evidence concerns the gene TP53 and hepatocellular carcinoma.