ULK1 and colorectal carcinoma: Multivariate regression analyses demonstrated that the amount of intratumor F. nucleatum was an independent predictor of CRC aggressiveness and recurrence post-chemotherapy with significant hazard ratios for predicting clinical outcome (189). ULK1/ATG7 -dependent autophagy contributed to F. nucleatum-mediated CRC resistance to OXA and 5-FU regimens (189).