ERBB2 and neoplasm: The humoral response in CRC may be directed towards several tumor-associated antigens, such as Carcinoembryonic antigen (CEA) (271, 272), Epidermal Growth Factor Receptor (EGFR) (273), Human Epidermal Growth Factor Receptor 2 (HER2 or ErbB2) (274), MUC5AC (275), and ribosomal P proteins (276) and facilitate antibody-dependent cellular cytotoxicity (30) (Figure 7B).