We have previously shown that MCAM blockade impairs the recruitment of MCAM+ T-cells to the CNS via the choroid plexus and delays the disease onset in EAE induced mice lacking integrin α4 expression in CD4+ T-cells and ameliorates the disease beyond the blocking of VLA-4 in a spontaneous model of MS (2D2 mice) (23). The gene discussed is CD4; the disease is myeloid sarcoma.