TGFB1 and neoplasm: TGF-β (Transforming Growth Factor β) receptor deregulation through TGF-β receptor 2 abnormalities (53), decreased expression of surface HLA class II molecules due to CD58 locus deletions (54) and impairment of Tumor-Associated Macrophages related to XPO1 and NRF1 abnormalities (55, 56) may also represent another player in immune evasion in RS.