XPO1-blocking drug Selinexor has been shown to slow down tumor growth in murine primary central nervous system lymphoma by shifting TAM polarization from PD-1 expressing M2-like macrophages toward PD-1 low-expressing M1 macrophages, providing evidence for the role of microenvironment remodeling in lymphoma (56). This evidence concerns the gene XPO1 and neoplasm.