Another micro-RNA cluster, miR-15a/16 does not harbor functions restricted to tumor suppressive properties, since it also regulates T-cell expansion and differentiation (48), B cell proliferation (49), contributes to the balance between T-cell activation and T-cell anergy (50), regulates PD-1 (Programmed Death 1) expression and IFNγ excretion by tumor-infiltrating CD8+ T-cells (51), and indirectly governs regulatory T-cell development (52). This evidence concerns the gene CD8A and neoplasm.