In a melanoma mouse model consisting in B16.SIY melanoma cells subcutaneously transplanted into immunocompetent 6-week old wild-type C57BL/6 mice, TL from the tumor microenvironment express very high levels of PD-L1 and indoleamine-2,3-dioxygenase, both induced by IFNγ production by CD8+ TLs (75). This evidence concerns the gene CD274 and neoplasm.