RIGI and viral infectious disease: Retinoic acid-inducible gene I (RIG-I)-like receptors (RLRs), Toll-like receptors (TLRs), and NOD-like receptors (NLRs) are the three main PRRs responsible for inducing the production of type I IFNs and inflammatory cytokines, which are important innate immune regulators during viral infections (Akira et al., 2006).