IL1B and vitiligo: Meanwhile, the important clue is that IL-1β, which is closely related to vitiligo activity, not only participates in the modulation of immune programs (Warnatsch et al., 2017; Yao Y. et al., 2017), but also enhances local antimicrobial peptides to potentiate microbiome remodeling (Yao X. et al., 2017).