Another of the genetic variants associated strongly with NASH, the I148M variant of patatin-like phospholipase domain-containing protein 3 (PNPLA3) appears to disrupt release of mono-unsaturated fatty acids (MUFAs), which activate peroxisome proliferator-activated receptor gamma coactivator 1-α (PGC1α) and nuclear factor erythroid 2-related factor 2 (NRF2). The gene discussed is NFE2L2; the disease is metabolic dysfunction-associated steatohepatitis.