In type 2 diabetes patients, twice-weekly administration of PF-05231023 for 4 weeks reduced body weight by about 5%, triglycerides by about 50%, and LDL-cholesterol by about 20% from baseline, while increasing HDL-cholesterol by about 15% and adiponectin 15- to 20-fold (183). This evidence concerns the gene ADIPOQ and type 2 diabetes mellitus.