Inhibition of NGF binding to the receptor TrkA in preclinical models strongly reduced mechanical, thermal and spontaneous facets of cancer-induced bone pain (Halvorson et al., 2005b; Jimenez-Andrade et al., 2011; Buehlmann et al., 2019), pancreatic cancer pain (Stopczynski et al., 2014; Amit et al., 2019), and oral cancer pain (Ye et al., 2011). This evidence concerns the gene NTRK1 and cancer.