Kosugi et al. (Kosugi et al., 2007) fed candesartan, an ARB, to nude mice of bladder cancer xenograft model and found that candesartan had significantly lower expression of vascular endothelial growth factor (VEGF) in mice; moreover, they showed that the tumor volume was half than that of paclitaxel treatment. Here, VEGFA is linked to neoplasm.