Kosugi et al. (Kosugi et al., 2007) fed candesartan, an ARB, to nude mice of bladder cancer xenograft model and found that candesartan had significantly lower expression of vascular endothelial growth factor (VEGF) in mice; moreover, they showed that the tumor volume was half than that of paclitaxel treatment. This evidence concerns the gene VEGFA and urinary bladder cancer.