PQR can resist anxiety like behavior caused by 72-h sleep deprivation, oxidative stress state, changes in mitochondrial enzyme complex activity, elevated serum corticosterone level, increased brain TNF-α level, and neuroinflammatory like signs in discrete brain regions Pretreatment with GABA agonist could enhance the protective effect of PQR, and the protective effect is more significant than itself (p < 0.05) (Chanana and Kumar, 2016). The gene discussed is TNF; the disease is Anxiety.