Notch1 expression and activation contribute to glial cell transformation and glioma growth/survival, migration/invasion through Ras (Kanamori et al., 2007), β-catenin, NF-κB, AKT activation and downregulation of PTEN (Zhang et al., 2012; El Hindy et al., 2013). The gene discussed is AKT1; the disease is glioma.