In hepatocellular carcinoma (HCC), TRPM7 activates RhoA, increases the cellular F-actin expression, increases myocardin-related transcription factors A and B (MRTFs) -Flaming A complex formation, therefore, facilitates MRTF nuclear localization and transcriptional activity that lead to cancer cell growth (Voringer et al., 2020). This evidence concerns the gene RHOA and cancer.