Results show that the percentage of apoptotic glioma cells increased from (17.59 + 5.32) to (19.16 + 6.4)% in the controls compared to those silenced by Notch1; and (14.29 + 3.15) to (18.87 + 5.57)% in TRPM7-wt transfected A172 cells compared to those co-transfected with TRPM7 and siNotch1. This evidence concerns the gene NOTCH1 and central nervous system cancer.