Comparatively, deletion of downstream autophagy genes Atg5 or Atg7 permitted development of benign tumors that failed to progress to malignant cancers (Takamura et al., 2011; Guo et al., 2013; Strohecker et al., 2013; Rao et al., 2014; Yang et al., 2014). This evidence concerns the gene ATG5 and neoplasm.