TP53 and diabetic kidney disease: For example, the pathways involve “complement and coagulation cascades,” which have been reported to play important roles in the progression of DKD (Wang et al., 2016c), and the “p53 signaling pathway” and “TGF-β signaling pathway,” which are closely associated with DKD (Zhang et al., 2011; Wang et al., 2016a; Mukhi et al., 2017; Xu et al., 2017a; Shelbaya et al., 2018; Sheng et al., 2018; Xiang et al., 2019).