In order to suppress invasion and proliferation of cervical, breast and pancreatic cancer cells, curcumin suppresses TGF-β signaling pathway through interfering with Wnt/β-catenin signaling pathway (Nna et al., 2013; Thacker and Karunagaran, 2015; Wang and Yan, 2016). Here, TGFB1 is linked to familial pancreatic carcinoma.