The current standard of care for ischemic stroke is acutely time-sensitive: administration of intravenous tPA is recommended within 4.5 h of stroke onset, and endovascular therapy in select patients within 24 h of stroke onset (Hacke et al., 2008; Berkhemer et al., 2015; Campbell et al., 2015; Goyal et al., 2015; Jovin et al., 2015; Saver et al., 2015, 2016; Albers et al., 2018; Nogueira et al., 2018). Here, PLAT is linked to stroke disorder.