As expected, mitophagy is widely impaired in respective models as well as in the brains of AD and PD patients, while the selective pharmacological enhancement of mitophagy can reverse several other pathological aspects, such as the generation of insoluble Aβ, Tau hyperphosphorylation, neuroinflammation, neuronal atrophy and cognitive impediments (Fang et al., 2019; Liu J. et al., 2019). The gene discussed is MAPT; the disease is Alzheimer disease.