Given that inflammation is the driving factor in the maturation of insulin resistance during obesity, T2DM and neurodegenerative diseases, including AD and PD (Tateya et al., 2013; Holscher, 2019), it is implied that AG enhances insulin sensitivity by suppressing systemic inflammation, hyperlipidemia and oxidative assault. The gene discussed is INS; the disease is obesity due to melanocortin 4 receptor deficiency.