This suggests that the loss of GHS-R1α/AG-signaling in immune cells contributes to the process of immune-senescence during aging, also known as “inflamm-aging.” Briefly, the process of inflamm-aging describes the gradual manifestation of an asymptomatic, chronic, systemic and low-grade inflammatory phenotype in the entire physiological system with age that contributes to development of aging-related diseases, such as insulin resistance, T2DM, AD, and PD (Xia et al., 2016). The gene discussed is GHSR; the disease is type 2 diabetes mellitus.