Analogical to AD, late-stage PD patients showed diminished levels of the LAMP1, LAMP2A, and heat shock cognate 70, which execute chaperone-mediated autophagy, yet displayed elevated LC3-II levels (symbolic for autophagosome accumulation) and α-synuclein inclusions in the SN pars compacta (SNpc) and/or the amygdala. The gene discussed is SNCA; the disease is Parkinson disease.