In the MSG-generated rat model of obesity and cognitive decline, the administration of the ghrelin analog GHRP-6 normalized the plasma concentrations of various hormones, decreased the abnormally elevated hippocampal pools of Aβ and acetylcholine and enhanced the spatial memory of these rodents (Kutty and Subramanian, 2014). The gene discussed is GHSR; the disease is obesity due to melanocortin 4 receptor deficiency.