MAPT and Alzheimer disease: The nod-like receptor protein 3 (NLRP3) inflammasome-associated propagation of neuroinflammation has also recently been identified in AD and PD, believed to sequentially involve Aß accumulation, the Aß-triggered inflammasome activation, inflammasome-induced cytokine production and the onset of Tau pathology in AD (Mamik and Power, 2017; Ising et al., 2019; Stancu et al., 2019).