Finally, we find that inhibition of NOX with VAS2870 did not inhibit STAT3 (Fig. 9H) in lung cancer cells and did not affect their transformed phenotype (Fig. 9I), suggesting that the transformation properties of oncogenic K-Ras–expressing lung cancer cells rely upon coupling of the AT1-R with STAT3 but not NOX. This evidence concerns the gene STAT3 and lung cancer.