ACE2 and viral infectious disease: The high expression of ACE2 in endothelial cells and the exposition to SARS-CoV-2 may generate an environment of constant inflammatory changes reflecting other clinical markers indicative of immune response such as leukocytosis (mainly neutrophilia), thrombocytopenia [119], endothelial damage and activation leading to thrombosis and critical illness [120] as seen in other viral infections [121, 122] but at a higher frequency in COVID-19 [120, 123].