CDC42 and hepatocellular carcinoma: In summary, we identified that CDC42 expression may be an independent prognostic factor in HCC patients via UCR and MCR analyses with data from the TCGA and ICGC datasets, and we found that CDC42 may affect the Wnt signaling pathway and M2 macrophage differentiation, which may prove to be a new gene for studying macrophage differentiation in HCC.