A recent study reports that, through up-regulating β-catenin signal, Notch signal, and Smad2/3 signal, exosome-derived LINC00960 can promote the malignant behaviors of low-grade bladder cancer cells and induce epithelial-mesenchymal transition, thus working as a potential liquid biomarker to monitor the progression of bladder cancer [26]. The gene discussed is SMAD2; the disease is urinary bladder carcinoma.