Conversely, the tumor suppressor nischarin that interacts with multiple signaling molecules, such as Rac1, LIM kinase (LIMK), liver kinase B1 (LKB1), p21 protein (Cdc42/Rac)-activated kinase 1 (PAK1), Rab14 and insulin receptor substrates 1-4, inhibits the formation of invadopodia and the expression of the integrin subunit α2, while it upregulates subunits α1, α4, and α7 [219]. The gene discussed is STK11; the disease is neoplasm.