Although it is not fully understood, the phenotypic and transcriptional characteristics of TRM cells might be induced and maintained by antigen recognition and cytokine signaling such as interleukin-15 (IL-15) and transforming growth factor-β (TGF-β) [7,13], which might be responsible for the TRM phenotype of most tumor-infiltrating T cells. This evidence concerns the gene TGFB1 and neoplasm.