MicroRNA-128 alleviated SSR-enhanced HeLa and CaSki cells’ adhesion and metastasis through suppressing numerous molecules, including ITGA5, ITGA5, sLex, CEACAM-6, MMP9, and MMP23. The evidence indicates that the nucleoid-based miR-128 strategy may be an attractive therapeutic strategy against tumor cells resistant to the shear flow of blood circulation and to prevent vascular adhesion and subsequent cervical cancer cell migration. This evidence concerns the gene ITGA5 and cervical cancer.