PIK3CA and hepatocellular carcinoma: In a recent study, Dai et al. showed that the combined sorafenib and capsaicin treatment inhibits the development and metastasis of HCC cells, both in vitro and in vivo, through a variety of mechanisms including the downregulation of EGFR and PI3K/Akt/mTOR pathways and decreasing MMP-2, MMP-9, Bcl-2, and mesenchymal markers vimentin and N-cadherin [52].