DOT1L and leukemia: Among the HMTs, disruptor of telomeric silencing 1-like (DOT1L), a methyltransferase specific for the histone H3 lysine 79 residue (H3K79), was recently reported as mediating the development and maintenance of mixed lineage leukemia (MLL)-rearranged leukemia and TNBC metastasis [13,15].