Finally, certain lymphoproliferative diseases are also associated with expression of COL6A1, COL18A1, MMP3 and TIMP1 [74], and a subset of patients with diffuse large B cell lymphoma and adverse prognosis show decreased expression of POSTN, SPARC, COL1A1, COL3A1,CSTK, MMP9 and LAMB3 [75]. The gene discussed is COL1A1; the disease is diffuse large B-cell lymphoma.