SPP1 and hematologic disorder: Many of the extracellular regulators involved in normal hematopoiesis are also important in leukemic hematopoiesis although their function in leukemic hematopoiesis is less well characterized; e.g., collagen/integrin/Rac1 [56,57], the CDH1 [58] and CDH2 cadherins [59], thrombospondin [60,61], TGFβ [62,63,64], osteopontin [65] and LOX/lipid metabolism [66,67] all seem to be important for leukemogenesis and/or chemosensitivity in hematological malignancies.