In their study, the expression levels of microtubule-associated protein 1A/1B-light chain 3 (LC3) and Beclin-1 were increased, and those of the ubiquitin-binding protein p62 were significantly decreased after THC treatment, indicating that THC modulated activation of the autophagy pathway, which was shown to play a protective role against brain trauma in rats [95]. The gene discussed is MAP1LC3A; the disease is brain injury.