Furthermore, Cxs are involved in entry (intravasation) and exit (extravasation) from the bloodstream [32,37,38], and several Cxs, including Cx43/Cx26/Cx30, have been implicated in the invasion of remote tissues, like prostate cancer bone metastasis (Cx43), breast cancer lymphatic vessel invasion (Cx26), and breast cancer and melanoma brain metastasis (Cx43 and Cx26) [32,33,34]. Here, GJA1 is linked to Familial prostate cancer.