MUTYH and Lynch syndrome: The majority of CRCs are sporadic (70–80%), and most of these cases are in people over 50 years of age, while only a small proportion are due to inherited forms, either familial adenomatous polyposis or mutY DNA glycosylase (MUTYH)-gene associated polyposis (<1%); non-polyposis hereditary CRC; or Lynch syndrome (2–5%).