BAD and breast carcinoma: For instance, in MCF-7 human breast cancer cells, SJW extract induces apoptosis by increasing the pro-apoptotic proteins Bcl 2 associated X (Bax) and Bcl 2 antagonist of cell death (Bad) and decreasing the anti-apoptotic proteins Bcl-2, B cell lymphoma extra-large (Bcl-xL), and phosphorylated form of Bad (pBad), finally leading to caspase 7 activation and cell death [173].