For instance, ginger extract protects against ethionine-induced rat hepato-carcinogenesis restraining TNF-α production and NF-κB activation [18]; astaxanthin exerts anti-inflammatory effects by hindering NF-κB signaling pathway and prevents hamster buccal pouch carcinogenesis [19]; ursolic acid and resveratrol inhibit skin tumor development by hampering pro-inflammatory cytokine expression and NF-κB/STAT-3 activation [20]. Here, NFKB1 is linked to skin neoplasm.