XIAP and hepatocellular carcinoma: Again, in hepatocellular carcinoma cell line, HPF significantly inhibits cell viability and cyclin D1 expression and induces loss of Δψm and downregulation of the anti-apoptotic proteins fetal liver LKB1 interacting protein c (c-FLIP), X linked inhibitor of apoptosis protein (XIAP) and myeloid leukemia cell differentiation protein (Mcl-1), finally triggering apoptosis [163].