DACH1 and neoplasm: As expected, given the marked difference in tumor mutation counts in both TCGA PCA and MCC, DACH1 wild-type patients had a median TMB of 6.02 and DACH1 mutated patients had a significantly higher median TMB of 24.0 (p-value = 4.29E-05) compared by the Wilcoxon rank sum test (Fig 7).