In addition, MLH1 (22/65, 33.85%, p = 2.63E-13), MSH2 (25/65, 38.46%, p = 2.87E-07), MSH6 (28/65, 43.1%, p = 1.01E-11), PMS2 (12/65, 18.5%, p = 3.79E-03), and POLE (28/65, 43.08%, 5.39E-08) mutations were more common in the MCC cohort than the TCGA PCA, while mutation frequency in PTEN, PIK3CA, and TP53 were not statistically difference in the two datasets. The gene discussed is TP53; the disease is Merkel cell skin cancer.