We compared frequencies of commonly found driver mutations including PTEN, PIK3CA, TP53, POLE, and the Lynch Syndrome-associated genes (MLH1, MSH2, MSH6, PMS2) using the enrichment test to determine whether the frequency of gene mutations in the MCC cohort was similar to that of the TCGA PanCancer Atlas (PCA) endometrial carcinoma and carcinosarcoma datasets. The gene discussed is MSH2; the disease is Merkel cell skin cancer.