POLE and Lynch syndrome: We performed a co-occurrence analysis using the Fisher’s exact test to determine whether DACH1 mutations are mutually exclusive or tend to co-occur with other gene mutations, with a significant co-occurrence pattern noted between DACH1 and two of the four Lynch Syndrome associated genes, MLH1 (p = 2.39E-04) and PMS2 (p = 3.67E-07) as well as DACH1 and POLE (p = 5.78E-08), shown in Table 5.