In addition, MLH1 (22/65, 33.85%, p = 2.63E-13), MSH2 (25/65, 38.46%, p = 2.87E-07), MSH6 (28/65, 43.1%, p = 1.01E-11), PMS2 (12/65, 18.5%, p = 3.79E-03), and POLE (28/65, 43.08%, 5.39E-08) mutations were more common in the MCC cohort than the TCGA PCA, while mutation frequency in PTEN, PIK3CA, and TP53 were not statistically difference in the two datasets. This evidence concerns the gene MSH6 and Merkel cell skin cancer.