ASCL1 and endometrial cancer: Our network analysis further supports this role in endometrial cancer by revealing three essential upregulated genes and their pathways with significant differences in expression between DACH1 mutated patients and wild-type, ASCL1, SOX2, LHX1. ASCL1 and SOX2 are important transcription factors involved in cell cycle regulation via interaction with Cyclin D [19–21], and LHX1 is a DNA-binding transcription factor.