CDKN1A and obesity due to melanocortin 4 receptor deficiency: Moreover, long‐term forced treadmill running showed contradictory effects on the markers of senescent cells, including p16INK4a, p21Cip1, and SA‐β‐Gal (Bao et al., 2020; Jang et al., 2019; Wong et al., 2019; Yoon et al., 2019; Zhang et al., 2016), although four out of five studies showed senolytic effects of exercise in specific tissues under obesity or aging conditions.