As shown in KM analysis, HCC patients with high CD13 level were significantly correlated with higher recurrence as well as poor prognosis after operation (median time‐to‐relapse [TTR]: 29.0 vs 48.0 months, P < .001; median OS: 45.5 vs 88.5 months, P < 0.001; Figure 2B,C). This evidence concerns the gene ANPEP and hepatocellular carcinoma.