ANPEP and hepatocellular carcinoma: To examine the role of p65 on mediating the effect of CD13 and sorafenib resistance in Huh7‐SR and MHCC97H‐SR cells, we used the p65 shRNA to deplete its expression in these cells and found that p65 knockdown could resensitize the SR phenotype in these two HCC cell lines (Figure 4C).