APC and colorectal carcinoma: The tumor‐suppressor gene APC ordinarily negatively regulates the canonical Wnt signaling pathway; nevertheless, in another pathway, APC downregulates PPARα binding to the lncRNA‐APC1 promoter to increase lncRNA‐APC1 expression, which suppresses CRC cell proliferation and metastasis by inhibiting sEVs production.31, 32