Cheng and colleagues revealed that sEVs‐miR‐146a‐5p, a major miRNA expressed in cancer stem cells (CSCs) that depends on Rab27a activation, decreased the number of tumor‐infiltrating CD8+ T cells, thus promoting the formation of an immunosuppressive cancer microenvironment in CRC.80 The gene discussed is RAB27A; the disease is neoplasm.