sEVs containing large amount of miR‐1246 that are derived from TP53 mutant CRC cells, miR‐203‐enriched sEVs and macrophage migration inhibitory factor‐containing sEVs originating from CRC cells are taken up by liver macrophages, resulting in the polarization of macrophages to M2 TAMs to increase transforming growth factor‐β (TGF‐β) levels,47, 67 subsequently inducing neighboring hepatic stellate cells to secrete fibronectin, and ultimately contributing to the recruitment of BMDCs that promote PMN formation.68 The gene discussed is FN1; the disease is colorectal carcinoma.