Furthermore, Lan et al have reported that M2 macrophage‐derived sEVs containing miR‐21‐5p and miR‐155‐5p downregulate the expression of BRG1 by directly binding to the BRG1 coding sequence in CRC cells, thus resulting in the metastasis of CRC.87 This evidence concerns the gene SMARCA4 and colorectal carcinoma.