Previously, we used the transgenic zebrafish model to demonstrate that liver‐specific overexpression of HBx and src oncogene promotes hepatocarcinogenesis, including steatosis and fibrosis in the earlier stages and hyperplasia, dysplasia, and HCC in the later stages,13 diet‐induced obesity can accelerate hepatocarcinogenesis.14 This evidence concerns the gene SRC and obesity due to melanocortin 4 receptor deficiency.