In this study, we investigated whether OF would be capable of reducing cancer incidence in different transgenic zebrafish HCC models including [HBx,src,p53−/+] transgenic zebrafish under diet induced obesity (DIO) developed HCC at 5 months of age,14 and CD36 transgenic zebrafish under high‐fat diet induced HCC at 1 month. This evidence concerns the gene TP53 and hepatocellular carcinoma.