We proved that OF binds to ASGR1/2 receptors on hepatoma cell, we also provided strong evidence that OF activates phosphorylation of STAT3, and then pSTAT3 will bind to P1 promoter of HNF4A, transcriptionally regulates the level of HNF4A, P1 isoform. The gene discussed is HNF4A; the disease is hepatocellular carcinoma.