We used low molecular weight (500‐1500 Da) OF in this study, and the novel finding is that OF reduced HCC formation in three different models: [HBx,src] and [HBx,src,p53−/+] diet‐induced obesity, and CD36 high‐fat diet transgenic fish models. This evidence concerns the gene TP53 and obesity due to melanocortin 4 receptor deficiency.