During hypertrophic stress, increased C/EBPβ downregulates the mir15a/mir16‐1 cluster, resulting in up‐regulation of multiple target proteins (INSR, IGF1R, AKT3, SGK1) in cardiomyocytes, causing increased activation of insulin/IGF1 signaling, ultimately causing cardiac hypertrophy and dysfunction. Here, CEBPB is linked to cardiac hypertrophy.