In the siXCR1 group, the levels of phosphorylated (p)‐JAK2 and p‐STAT3 were significantly upregulated which will then activate the JAK/STAT signaling pathway, while those of p‐JAK1, p‐JAK3, p‐STAT1, p‐STAT2, and p‐STAT4 were slightly changed or unchanged, indicating that JAK2 and STAT3 are the key proteins related to the indicated biological roles of XCR1 in ccRCC cells (Figure 5e). This evidence concerns the gene STAT3 and nonpapillary renal cell carcinoma.